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  RNA Oligonucleotides

TriLink is an industry leader in manufacturing high quality RNA oligos for research, diagnostics, OEM and therapeutics. We specialize in challenging constructs, such as siRNA, microRNA and aptamers, as well as scaling up to mid-scale quantities, 50 mg to multiple grams. Visit OligoBuilder® to price and order your RNA oligonucleotide.

Looking for long RNA, 100+ bases? See TriLink's Long RNA Synthesis by transcription service.

Over the last two decades, there has been significant progress in the development of oligonucleotides as therapeutics. RNA, DNA and RNA/DNA chimeric oligos have been used as antisense inhibitors, aptamers, CpG immunostimulatory molecules, molecular decoys and as RNA interference (RNAi) triggers. Antisense therapeutics are currently experiencing a renaissance, with very promising results in preclinical studies in non-human primates and in human clinical trials.

RNAi is a phenomenon in which the introduction of double-stranded RNA into a cell results in sequence-specific gene silencing. RNAi is a powerful research tool and a promising new class of potential therapeutics for RNA oligonucleotides. Investigations into the mechanisms of RNAi have led to the discovery of microRNAs, which are thought to regulate about half of all genes. Oligonucleotide based microRNA mimics and inhibitors are exciting new therapeutic research tools. Aptamers are also showing promise as therapeutics in animal models and are likely to be useful in the field of proteomics.

TriLink is a key supplier of RNA and DNA oligonucleotides for pre-clinical research. We specialize in highly modified oligos, including RNA oligonucleotides and derivatives such as 2' O-Methyl RNA, 2' Fluoro RNA, as well as thioated versions and conjugation to molecules such as PEG and cholesterol.

TriLink has optimized the synthesis and purification of RNA oligos. Every oligonucleotide manufactured at TriLink undergoes quality control analysis by PAGE, HPLC and/or MS. Further service options are available including additional purifications and analyses, annealing, aliquotting and large batch synthesis up to multiple grams final product. We are here to support your RNA research through our expertise in high quality nucleic acid synthesis and modification and excellent technical support.

 

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