play

GMP Manufacturing of Messenger RNA Therapeutics and Vaccines: Case Study of a Self-Amplifying SARS CoV-2 Vaccine

In this presentation Jessica Madigan, Director of Business Development will discuss, investigative mRNA vaccine programs scale from target-centric research to progressing candidates through the drug development process, challenges arise when determining the optimal path forward. 

play

SpotLight Workshop: CleanCap AU

This webinar presented by Dr. Anton McCaffrey will focus on the uses and value of CleanCap AU. CleanCap Reagent AU is designed for the co-transcriptional capping of mRNA to produce an mRNA with naturally occurring Cap 1.

play

Base Editing: Putting Precision into Genomic Medicine

In this presentation, Dr. Nicole Gaudelli will discuss how her group has transformed off-the-shelf base editors from a technology developed in academia to a promising therapeutic tool through engineering, screening, and directed evolution.

play

CRISPR-Based In Vivo Genome Editing and Base Editing

In this webinar, Dr. Wen Xue, Assistant Professor, RNA Therapeutics Institute at the University of Massachusetts Medical School will present, a modular delivery strategy for homology-directed repair by combining lipid nanoparticle delivery of Cas9 mRNA with adeno-associated viruses (AAV) encoding a sgRNA and a repair template.

play

Self-Amplifying mRNA Vaccines for Pandemic Rapid Response

In this webinar, you will hear from Dr. Andy Geall about data innovations from seven years of research at Novartis Vaccines on self-amplifying mRNA technology and how this approach could enable the concept of vaccines on demand as a rapid response to a real threat.

play

SpotLight Workshop: CleanCap

We are pleased to introduce a new type of educational event. The TriLink SpotLight Workshops are designed to be focused and impactful sessions with topic experts that allow you to learn and interact with Q&A. Our first workshop is on our proprietary mRNA capping technology — CleanCap® featuring Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies. 

play

A CRISPR Vision for the Future of Cell Therapy

In this webinar, T.J. Cradick, PhD, who was until recently head of genome editing at CRISPR Therapeutics, will introduce how genome editing is used to engineer cell therapies.

play

WVC COVID-19 Webinar: Panel on Vaccine Trial Data, Antibodies and Safety

This panel focuses on the lessons learned from COVID-19 vaccine human trials to date: our current understanding on the evolving trial data, neutralizing antibodies and safety of these COVID-19 vaccine candidates.

play

Vaccine and Trial Efforts Against COVID-19

In this Webinar Dr. Tal Zaks, CMO at Moderna, will discuss vaccine and trial efforts against COVID-19

play

SARS-CoV-2: Going Viral

In this Webinar Dr. Gregory A. Poland, Director of Mayo Vaccine Research Group at the Mayo Clinic will discuss, SARS-CoV-2: Going Viral.

play

Coronaviruses in Livestock: Vaccines and International Transport of Virus

In this Webinar Dr. Mark Kehrli, Center Director at the National Animal Disease Center will discuss, Coronaviruses in Livestock: Vaccines and International Transport of Viruses.

play

COVID-19: A Prototype Pathogen Demonstration Project for Pandemic Preparedness

In this Webinar Dr. Barney S. Graham, Deputy Director, VRC, NIAID NIH will discuss, COVID-19: A prototype pathogen demonstration project for pandemic preparedness.

play

Why Use mRNA: Video 1 of 8 from the TIDES 2018 Workshop by Dr. Anton McCaffrey.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses the benefits of using mRNA for manufacturing therapeutics.

play

mRNA Applications: Summarizing mRNA applications that include genome engineering, gene replacement, and immunobiology. Part 2 of 8 of the TIDES 2018 workshop series by Dr. Anton McCaffrey.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses, mRNA applications, including gene engineering, gene replacement and immunobiology.

play

mRNA Biology: Video 3 of 8 from the TIDES 2018 Workshop featuring Dr. Anton McCaffrey. Includes biology of mRNA location and sensor recognition.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses the biology behind mRNA therapeutics.

play

Manufacturing Design Considerations: Video 4 of 8 from the TIDES 2018 Workshop featuring Dr. Anton McCaffrey. Includes: planning the optimal mRNA, mRNA synthesis, mRNA manufacturing processes, research phase, plasmid template, and poly A polymerase.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses planning, manufacturing design considerations and processes involved with research and clinical applications.

play

mRNA Capping: Video 5 of 8 from the TIDES 2018 Workshop featuring Dr. Anton McCaffrey. m6Am, Cap 0, Cap 1, and Cap 2 explained in this summary of endogenous cap structures.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses the cap structures .m6Am, Cap 0, Cap 1, and Cap 2 for optimal mRNA synthesis.

play

In Vitro mRNA Capping: Video 6 of 8 TIDES 2018 featuring Dr. Anton McCaffrey discussing mRNA capping methods, capping characteristics, ARCA, CleanCap, and comparison data.

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses the capping characteristics, capping methods and comparison data between legacy capping methods ARCA, and CleanCap®, TriLink’s, novel, new capping technology.

play

Chemical Modification of mRNA: Part 7 of 8 of the TIDES 2018 workshop series by Dr. Anton McCaffrey. Includes topics surrounding modified RNA sequence space, sequence engineering, uridine depletion, purification methods, effect of cap structures, and var

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses chemical modification of mRNA including purification methods and sequence engineering.

play

Design & Manufacturing of Chemically Modified mRNA Therapeutics: Design and Manufacturing of Chemically Modified Messenger RNA Therapeutics - Entire Video TIDES 2018 Workshop by Dr. Anton McCaffrey

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses, the Design & Manufacturing of Chemically Modified mRNA Therapeutics: This complete video highlights mRNA therapeutic manufacturing from research to clinical applications.

play

The Path to GMP Production: Video 8 of 8 from the TIDES 2018 workshop series by Dr. Anton McCaffrey

In this video Dr. Anton McCaffrey, Senior Director of Emerging Science and Innovation, at TriLink BioTechnologies discusses, the path to GMP production including planning and timelines.

play

Advantages of In vivo DNA Barcoding in Nanoparticle Selection: Quantifying how thousands of nanoparticles deliver nucleic acids in vivo using DNA barcodes.

In this video James Dahlman, PhD, Assistant Professor, Department of Biomedical Engineering at the Georgia Institute of Technology discusses, RNA therapeutics and the role of  in vivo DNA barcoding in nanoparticle selection.

""