2'-O-Methyladenosine-5'-Triphosphate - (N-1015)
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2'-O-Methyladenosine-5'-Triphosphate is an ATP analog which is methylated at the 2'-O position of the ribose sugar. Methylation at this position results in increased stability of the resulting RNA strand against base hydrolysis and nuclease cleavage. This makes it a useful NTP for aptamer synthesis where increased variation in nucleotide composition along with increased nuclease resistance are desired.Â
| Catalog No | N-1015 |
|---|---|
| Purity | ≥95% by AX-HPLC |
| Extinction Coefficient | 15,400 Lmol-1cm-1 at 258 nm |
| Molecular Formula | C11H18N5O13P3 (free acid) |
| Molecular Weight | 521.20 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 2'-O-Methyl-ATP |
| Application | Aptamers, Epigenetics/DNA Damage |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Sugar Type(s) | 2'-O-Methyl |
| Nucleotide Category | Sugar Modified |
N-1015 Safety Data Sheet
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