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7-Deazaguanosine-5'-Triphosphate - (N-1044)

7-Deaza-GTP
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N-1044
Product Catalog # Unit Size Price Qty
N-1044

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Description
7-Deazaguanosine-5'-Triphosphate is a guanosine triphosphate analog which lacks a nitrogen at the N7 position of the nucleobase. Replacement of this nitrogen atom with a carbon atom results in diminished structure of the major groove in DNA and may disrupt base stacking, but does not interfere with Watson-Crick base pairing. This is desirable for applications such as amplification and sequencing of GC-rich nucleic acid sequences.
Product details
Catalog No N-1044
Purity ≥90% by AX-HPLC
Extinction Coefficient 9,145 Lmol-1cm-1 at 259 nm
Molecular Formula C11H17N4O14P3 (free acid)
Molecular Weight 522.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 7-Deaza-GTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Guanosine
Sugar Type(s) RNA
Nucleotide Category Base Modified RNA
Technical documents

N-1044 Safety Data Sheet

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Intellectual property

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.

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References
  1. Chugani, S. A.; Parsek, M. R.; Chakrabarty, A. M. . Transcriptional repression mediated by LysR-type regulator CatR bound at multiple binding sites.
  2. Amara, Amro A.; Rehm, Bernd H. A. . Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.
  3. Paranagama, Naduni; Bonnett, Shilah A.; Alvarez, Jonathan; Luthra, Amit; Stec, Boguslaw; Gustafson, Andrew; Iwata-Reuyl, Dirk; Swairjo, Manal A. . Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB.
  4. Waldron, Joseph A.; Raza, Farheen; Le Quesne, John . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
  5. Nakamura, Akiyoshi; Wang, Daole; Komatsu, Yasuo . Molecular mechanism of substrate recognition and specificity of tRNA(His) guanylyltransferase during nucleotide addition in the 3'-5' direction.
  6. Herviou, P;Le Bras, M;Dumas, L;Hieblot, C;Gilhodes, J;Cioci, G;Hugnot, JP;Ameadan, A;Guillonneau, F;Dassi, E;Cammas, A;Millevoi, S; . hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
  7. Waldron, JA;Raza, F;Le Quesne, J; . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes
  8. Ebenhoch, R;Prinz, S;Kaltwasser, S;Mills, DJ;Meinecke, R;R . A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
  9. Ebenhoch, R;Bauer, M;Reinert, D;Kersting, A;Huber, S;Schmid, A;Hinz, I;Feiler, M;M . Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP
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