7-Deazaguanosine-5'-Triphosphate - (N-1044)
7-Deaza-GTP
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N-1044
Description
7-Deazaguanosine-5'-Triphosphate is a guanosine triphosphate analog which lacks a nitrogen at the N7 position of the nucleobase. Replacement of this nitrogen atom with a carbon atom results in diminished structure of the major groove in DNA and may disrupt base stacking, but does not interfere with Watson-Crick base pairing. This is desirable for applications such as amplification and sequencing of GC-rich nucleic acid sequences.
Product details
| Catalog No | N-1044 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 9,145 Lmol-1cm-1 at 259 nm |
| Molecular Formula | C11H17N4O14P3 (free acid) |
| Molecular Weight | 522.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 7-Deaza-GTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Guanosine |
| Sugar Type(s) | RNA |
| Nucleotide Category | Base Modified RNA |
Technical documents
N-1044 Safety Data Sheet
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Certificate of analysis
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Intellectual property
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References
- Chugani, S. A.; Parsek, M. R.; Chakrabarty, A. M. . Transcriptional repression mediated by LysR-type regulator CatR bound at multiple binding sites.
- Amara, Amro A.; Rehm, Bernd H. A. . Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.
- Paranagama, Naduni; Bonnett, Shilah A.; Alvarez, Jonathan; Luthra, Amit; Stec, Boguslaw; Gustafson, Andrew; Iwata-Reuyl, Dirk; Swairjo, Manal A. . Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB.
- Waldron, Joseph A.; Raza, Farheen; Le Quesne, John . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
- Nakamura, Akiyoshi; Wang, Daole; Komatsu, Yasuo . Molecular mechanism of substrate recognition and specificity of tRNA(His) guanylyltransferase during nucleotide addition in the 3'-5' direction.
- Herviou, P;Le Bras, M;Dumas, L;Hieblot, C;Gilhodes, J;Cioci, G;Hugnot, JP;Ameadan, A;Guillonneau, F;Dassi, E;Cammas, A;Millevoi, S; . hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
- Waldron, JA;Raza, F;Le Quesne, J; . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes
- Ebenhoch, R;Prinz, S;Kaltwasser, S;Mills, DJ;Meinecke, R;R . A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
- Ebenhoch, R;Bauer, M;Reinert, D;Kersting, A;Huber, S;Schmid, A;Hinz, I;Feiler, M;M . Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP
