TriLink specializes in challenging constructs, such as siRNA, microRNA and aptamers, as well as scaling up to mid-scale quantities, 50 mg to multiple grams. TriLink is the industry leader in manufacturing high quality RNA oligos for research, diagnostics, OEM, and therapeutics. For long RNAs with 100+ bases please see the TriLink mRNA custom synthesis long RNA synthesis by in vitro transcription service.
TriLink is a key supplier of RNA and DNA oligonucleotides for pre-clinical and therapeutic research. We specialize in highly modified oligos, including RNA oligonucleotides and derivatives such as 2' O-Methyl RNA, 2' Fluoro RNA, as well as thioated versions and conjugation to molecules such as PEG and cholesterol. RNA, DNA and RNA/DNA chimeric oligos have been used as antisense inhibitors, aptamers, CpG immunostimulatory molecules, molecular decoys, and as RNA interference (RNAi) triggers.
Our RNA specialty constructs include:
Over the last two decades, there has been significant progress in the development of oligonucleotides as therapeutics. RNA, DNA, and RNA/DNA chimeric oligos have been used as antisense inhibitors, aptamers, CpG immunostimulatory molecules, molecular decoys, and RNA interference (RNAi) triggers. Antisense therapeutics are currently experiencing a renaissance, with very promising results in preclinical studies in non-human primates and in human clinical trials.
RNAi is a phenomenon in which the introduction of double-stranded RNA into a cell results in sequence-specific gene silencing. RNAi is a powerful research tool and a promising new class of potential therapeutics for RNA oligonucleotides. Investigations into the mechanisms of RNAi have led to the discovery of microRNAs, which are thought to regulate about half of all genes. Oligonucleotide based microRNA mimics and inhibitors provide an exciting opportunity for new therapeutics and research tools. Aptamers are also showing promise as therapeutics in animal models and are gaining popularity in the fields of proteomics and targeted drug delivery.
TriLink is a key supplier of RNA and DNA oligonucleotides for pre-clinical research. We specialize in highly modified oligos, including RNA oligonucleotides and derivatives such as 2' O-methyl RNA, 2' fluoro RNA, and thioated nucleotides, as well as conjugation molecules such as PEGs, cholesterol, peptides, and antibody conjugates for cellular delivery.
TriLink has optimized the synthesis and purification of RNA oligos. Every oligonucleotide manufactured at TriLink undergoes quality control analysis by PAGE, HPLC, and/or MS. Further service options are available including additional purifications and analyses, annealing, aliquoting, and formulation. Synthesis is available from 1 micromole up to multiple grams of final product. We are here to support your RNA research through our expertise in high quality modified nucleic acid synthesis and excellent technical support.
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