2-Amino-2'-deoxyadenosine-5'-Triphosphate - (N-2003)
2,6-Diaminopurine-2'-deoxyribose-5'-Triphosphate, 2-Amino-dATP, DAP-drTP
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N-2003
Description
Substitution of 2-Amino-2'-deoxyadenosine (also known as 2,6-Diaminopurine-2'-deoxyribose) for adenine in DNA can result in increased stabilization of the DNA duplex. Diaminopurine base pairs with thymine forming three intramolecular hydrogen bonds versus two for adenine.
Product details
| Catalog No | N-2003 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 8,743 Lmol-1cm-1 at 279 nm |
| Molecular Formula | C10H17N6O12P3 (free acid) |
| Molecular Weight | 506.20 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 2,6-Diaminopurine-2'-deoxyribose-5'-Triphosphate, 2-Amino-dATP, DAP-drTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Sugar Type(s) | DNA |
| Nucleotide Category | Base Modified DNA |
Technical documents
N-2003 Safety Data Sheet
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References
- Wood, David O.; Dinsmore, Michael J.; Bare, Grant A.; Lee, Jeremy S. . M-DNA is stabilised in G*C tracts or by incorporation of 5-fluorouracil.
- Kutyavin, Igor V. . Use of Base-Modified Duplex-Stabilizing Deoxynucleoside 5′-Triphosphates To Enhance the Hybridization Properties of Primers and Probes in Detection Polymerase Chain Reactionâ€ÂÂ
- Kawai, Kiyohiko; Kodera, Haruka; Majima, Tetsuro . Photocatalytic formation of I-I bonds using DNA which enables detection of single nucleotide polymorphisms.
- Devadoss, Babho; Lee, Irene; Berdis, Anthony J. . Enhancing the "A-rule" of translesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates.
- Zhang, Xuemei; Motea, Edward; Lee, Irene; Berdis, Anthony J. . Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy during DNA Polymerization and Pyrophosphorolysis
- Patro, Jennifer N.; Urban, Milan; Kuchta, Robert D. . Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha.
- Trostler, Michael; Delier, Alison; Beckman, Jeff; Urban, Milan; Patro, Jennifer N.; Spratt, Thomas E.; Beese, Lorena S.; Kuchta, Robert D. . Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
- Fernández-Sierra, Mónica; Shao, Qing; Fountain, Chandler; Finzi, Laura; Dunlap, David . E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.
- Strobel, E; . Preparation and Characterization of Internally Modified DNA Templates for Chemical Transcription Roadblocking
