2'-Azido-2'-deoxycytidine-5'-Triphosphate - (N-1028)
2'-Azido-dCTP
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N-1028
Description
2'-Azido-2'-deoxycytidine-5'-Triphosphate contains an azido group at the 2' position which allows labeling of DNA and RNA with alkyne-containing "click" reagents. 2'-Azido-dUTP is also used in aptamer synthesis to expand on the canonical nucleotides and increase variation in binding characteristics.
Product details
| Catalog No | N-1028 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 9,100 Lmol-1cm-1 at 271 nm |
| Molecular Formula | C9H15N6O13P3 (free acid) |
| Molecular Weight | 508.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 2'-Azido-dCTP |
| Application | Aptamers |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Cytidine |
| Sugar Type(s) | 2'-Azido |
| Nucleotide Category | Sugar Modified |
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Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.
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References
- Maga, G.; Amacker, M.; Hübscher, U.; Gosselin, G.; Imbach, J. L.; Mathé, C.; Faraj, A.; Sommadossi, J. P.; Spadari, S. . Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and
- Kumaki, Yohichi; Day, Craig W.; Smee, Donald F.; Morrey, John D.; Barnard, Dale L. . In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections.
- Lauridsen, Lasse H.; Rothnagel, Joseph A.; Veedu, Rakesh N. . Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers.
- Cozens, Christopher; Pinheiro, Vitor B.; Vaisman, Alexandra; Woodgate, Roger; Holliger, Philipp . A short adaptive path from DNA to RNA polymerases.
- Ravichandran, Kanchana; Minnihan, Ellen C.; Lin, Qinghui; Yokoyama, Kenichi; Taguchi, Alexander T.; Shao, Jimin; Nocera, Daniel G.; Stubbe, JoAnne . Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.
