2' Fluoro RNA

2' F RNA
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This modification is available as part of a custom oligonucleotide configuration. Please use OLIGObuilder™ to generate pricing and order or contact us to speak with a customer service representative.

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Product Details

OLIGObuilder Code [fA], [fC], [fG], [fU]
Other Name(s) 2' F RNA
Application Antisense/RNAi, Aptamers, CRISPR
Oligo Modification Type Backbone


References

Shu, Dan; Shu, Yi; Haque, Farzin; Abdelmawla, Sherine; Guo, Peixuan . Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics.

Hernandez, Frank J.; Stockdale, Katie R.; Huang, Lingyan; Horswill, Alexander R.; Behlke, Mark A.; McNamara, James O. 2nd . Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media.

Manoharan, Muthiah; Akinc, Akin; Pandey, Rajendra K.; Qin, June; Hadwiger, Philipp; John, Matthias; Mills, Kathy; Charisse, Klaus; Maier, Martin A.; Nechev, Lubomir; Greene, Emily M.; Pallan, Pradeep S.; Rozners, Eriks; Rajeev, Kallanthottathil G.; Egli, Martin . Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

Pallan, Pradeep S.; Greene, Emily M.; Jicman, Paul Andrei; Pandey, Rajendra K.; Manoharan, Muthiah; Rozners, Eriks; Egli, Martin . Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.

Blidner, Richard A.; Hammer, Robert P.; Lopez, Mandi J.; Robinson, Sandra O.; Monroe, W. Todd . Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture.

Morrissey, David V.; Lockridge, Jennifer A.; Shaw, Lucinda; Blanchard, Karin; Jensen, Kristi; Breen, Wendy; Hartsough, Kimberly; Machemer, Lynn; Radka, Susan; Jadhav, Vasant; Vaish, Narendra; Zinnen, Shawn; Vargeese, Chandra; Bowman, Keith; Shaffer, Chris S.; Jeffs, Lloyd B.; Judge, Adam; MacLachlan, Ian; Polisky, Barry . Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs.

Layzer, Juliana M.; McCaffrey, Anton P.; Tanner, Alice K.; Huang, Zan; Kay, Mark A.; Sullenger, Bruce A. . In vivo activity of nuclease-resistant siRNAs.

Rhie, Alexandre; Kirby, Louise; Sayer, Natalie; Wellesley, Rosanna; Disterer, Petra; Sylvester, Ian; Gill, Andrew; Hope, James; James, William; Tahiri-Alaoui, Abdessamad . Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

Chiu, Ya-Lin; Rana, Tariq M. . siRNA function in RNAi: a chemical modification analysis.

Khati, Makobetsa; Schüman, Michael; Ibrahim, Jamal; Sattentau, Quentin; Gordon, Siamon; James, William . Neutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 2'F-RNA aptamers.

Yazbeck, Daniel R.; Min, Kyung-Lyum; Damha, Masad J. . Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1.

Sabahi, A.; Guidry, J.; Inamati, G. B.; Manoharan, M.; Wittung-Stafshede, P. . Hybridization of 2'-ribose modified mixed-sequence oligonucleotides: thermodynamic and kinetic studies.

Ruckman, J.; Green, L. S.; Beeson, J.; Waugh, S.; Gillette, W. L.; Henninger, D. D.; Claesson-Welsh, L.; Janjić, N. . 2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain.

Kubik, M. F.; Bell, C.; Fitzwater, T.; Watson, S. R.; Tasset, D. M. . Isolation and characterization of 2'-fluoro-, 2'-amino-, and 2'-fluoro-/amino-modified RNA ligands to human IFN-gamma that inhibit receptor binding.

Fell, P. L.; Hudson, A. J.; Reynolds, M. A.; Usman, N.; Akhtar, S. . Cellular uptake properties of a 2'-amino/2'-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA.

Beigelman, L.; McSwiggen, J. A.; Draper, K. G.; Gonzalez, C.; Jensen, K.; Karpeisky, A. M.; Modak, A. S.; Matulic-Adamic, J.; DiRenzo, A. B.; Haeberli, P. . Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance.

Kawasaki, A. M.; Casper, M. D.; Freier, S. M.; Lesnik, E. A.; Zounes, M. C.; Cummins, L. L.; Gonzalez, C.; Cook, P. D. . Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.

Pieken, W. A.; Olsen, D. B.; Benseler, F.; Aurup, H.; Eckstein, F. . Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes.