5-Fluoro-2'-deoxyuridine-5'-Triphosphate - (N-2022)
5-F-dUTP, 5-Fl-dUTP, 5-Fluoro-dUTP
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N-2022
Product details
| Catalog No | N-2022 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 7,350 Lmol-1cm-1 at 268 nm |
| Molecular Formula | C9H14N2O14P3F (free acid) |
| Molecular Weight | 486.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 5-F-dUTP, 5-Fl-dUTP, 5-Fluoro-dUTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Thymidine, Uridine |
| Sugar Type(s) | DNA |
| Nucleotide Category | Base Modified DNA |
Technical documents
N-2022 Safety Data Sheet
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References
- Wood, David O.; Dinsmore, Michael J.; Bare, Grant A.; Lee, Jeremy S. . M-DNA is stabilised in G*C tracts or by incorporation of 5-fluorouracil.
- Zhang, Xuemei; Motea, Edward; Lee, Irene; Berdis, Anthony J. . Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy during DNA Polymerization and Pyrophosphorolysis
- Baehr, Carly A.; Huntoon, Catherine J.; Hoang, Song-My; Jerde, Calvin R.; Karnitz, Larry M. . Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.
- Yoon, Sorah; Huang, Kai-Wen; Reebye, Vikash; Spalding, Duncan; Przytycka, Teresa M.; Wang, Yijie; Swiderski, Piotr; Li, Lin; Armstrong, Brian; Reccia, Isabella; Zacharoulis, Dimitris; Dimas, Konstantinos; Kusano, Tomokazu; Shively, John; Habib, Nagy; Rossi, John J. . Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth.
- Zeng, Xuehuo; Hernandez-Sanchez, Wilnelly; Xu, Mengyuan; Whited, Tawna L.; Baus, Diane; Zhang, Junran; Berdis, Anthony J.; Taylor, Derek J. . Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner.
