5-Propynyl-2'-deoxyuridine-5'-Triphosphate - (N-2017)
5-Propynyl-dUTP
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N-2017
Description
The addition of a propynyl group at the C5 position of pyrimidine nucleotides is highly duplex stabilising, resulting in a higher melting temperature of the resulting DNA-DNA or DNA-RNA hybrid.
Product details
| Catalog No | N-2017 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 11,050 Lmol-1cm-1 at 291 nm |
| Molecular Formula | C12H17N2O14P3 (free acid) |
| Molecular Weight | 506.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 5-Propynyl-dUTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Thymidine, Uridine |
| Sugar Type(s) | DNA |
| Nucleotide Category | Base Modified DNA |
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Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.
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References
- Kutyavin, Igor V. . Use of Base-Modified Duplex-Stabilizing Deoxynucleoside 5′-Triphosphates To Enhance the Hybridization Properties of Primers and Probes in Detection Polymerase Chain Reactionâ€ÂÂ
- Zhang, Xuemei; Motea, Edward; Lee, Irene; Berdis, Anthony J. . Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy during DNA Polymerization and Pyrophosphorolysis
