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6-Thio-2'-deoxyguanosine-5'-Triphosphate - (N-2045)

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The nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is a substrate for telomerase and is incorporated into de novo synthesized telomeres. This results in modified telomeres, leading to telomere dysfunction in cells expressing telomerase, such as cancer cells.
Product details
Catalog No N-2045
Purity ≥90% by AX-HPLC
Extinction Coefficient 24,800 Lmol-1cm-1 at 341 nm
Molecular Formula C10H16N5O12P3S (free acid)
Molecular Weight 523.20 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 6-Thio-dGTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Guanosine
Sugar Type(s) DNA
Nucleotide Category Base Modified DNA
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N-2045 Safety Data Sheet

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