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Araadenosine-5'-Triphosphate - (N-1048)

Ara-ATP, Vidarabine triphosphate
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This product is now available upon request as a custom synthesis. It is not maintained as a stocked item.

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9-β-D-Arabinofuranosyladenine 5’-triphosphate (ara-ATP) is an active form of 9-β-D-arabinofuranosyladenine (Vidarabine) - a synthetic sugar-modified analog of natural adenosine - with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2) and varicella-zoster virus (VZV). When used with viral DNA polymerase, ara-ATP competes with dATP for incorporation into DNA leading to a termination of DNA synthesis. Ara-ATP is an inhibitor of human ribonucleotide reductase which is one of the key enzymes responsible for the synthesis of 2’-deoxyribonucleotides required for DNA synthesis. Ara-ATP also inhibits RNA polyadenylation which is essential for HIV-1 and other retroviruses. It is an inhibitor for S-adenosylhomocysteine hydrolase thus preventing trans-methylation reaction.
Product details
Catalog No N-1048
Purity ≥90% by AX-HPLC
Extinction Coefficient 15,400 Lmol-1cm-1 at 258 nm
Molecular Formula C10H16N5O13P3 (free acid)
Molecular Weight 507.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) Ara-ATP, Vidarabine triphosphate
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Adenosine
Sugar Type(s) Ara
Nucleotide Category Sugar Modified
Technical documents

N-1048 Safety Data Sheet

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