Araadenosine-5'-Triphosphate - (N-1048)
Ara-ATP
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N-1048
Description
9-β-D-Arabinofuranosyladenine 5’-triphosphate (ara-ATP) is an active form of 9-β-D-arabinofuranosyladenine (Vidarabine) - a synthetic sugar-modified analog of natural adenosine - with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2) and varicella-zoster virus (VZV).
When used with viral DNA polymerase, ara-ATP competes with dATP for incorporation into DNA leading to a termination of DNA synthesis.
Ara-ATP is an inhibitor of human ribonucleotide reductase which is one of the key enzymes responsible for the synthesis of 2’-deoxyribonucleotides required for DNA synthesis. Ara-ATP also inhibits RNA polyadenylation which is essential for HIV-1 and other retroviruses. It is an inhibitor for S-adenosylhomocysteine hydrolase thus preventing trans-methylation reaction.
Product details
| Catalog No | N-1048 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 15,400 Lmol-1cm-1 at 258 nm |
| Molecular Formula | C10H16N5O13P3 (free acid) |
| Molecular Weight | 507.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | Ara-ATP |
| Application | Aptamers |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Sugar Type(s) | Ara |
| Nucleotide Category | Sugar Modified |
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Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.
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