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Research Update

Modified mRNA: Getting to the Heart of Gene Therapy

Messenger RNA for clinical use is not a new concept. In 2000 Rammensee, Jung and colleagues accidentally discovered that direct injection of messenger RNA elicits an immune response. This discovery led to years of research utilizing mRNA for vaccine development. A variety of characteristics gives mRNA a natural advantage over traditional vaccines.

Recently, the use of mRNA as a therapeutic agent has been gaining momentum again, this time as a tool for gene replacement.

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Don't miss the Fluorescent Biomolecules Conference in La Jolla, CA, August 6-9.
 
Recent Blog Post

Venter’s Latest Venture: Increasing Human Longevity

  • The Quest to Make 100 the New 60
  • Aiming to Sequence 100,000 Human Genomes Per Year (Wow!)
  • Adding Genomes, Microbiomes, and Metabolomes to Health Records May Lead to Better Health and Longevity

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Venter relaxing on his 95-foot sailboat/research vessel. Photo: Rick Friedman/Corbis, theguardian.com
 

Cellular RNA consists of four major nucleosides and about 100 minor nucleosides, which are generated post-transcriptionally by enzymatic modification of the four major bases, or in exceptional cases, by base replacement. These natural minor nucleotides perform a large number of functions, some of which are yet to be discovered. We are continually expanding our catalog of naturally occurring RNA analogs to aide in this research.

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If you don’t see the analog you need, just ask!

 
Previous Blog Post

Crowdfunding: Science & Startups Go Social
  • Websites Proliferate for “Reaching out to Engage” for Needed Dollars
  • Academics, Universities and Startups are Now Crowdfunding
  • Some Projects Attract Big Buck But Most Get Little

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