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Research Update

Bypassing Molecular Evolution by Targeting Toll-like Receptors

Vaccines and immunotherapies utilize the host’s immune system to provide protection against a particular pathogen or disease. While various approaches exist, there are common hurdles that all immune-based approaches must overcome. Primarily, they must elicit an “appropriate” immune response through an antigen containing a cognate sequence to the pathogen. This task can be particularly challenging for pathogens that are prone to mutate. One solution is to target the host’s innate immune system to boost its response to invading pathogens. This method has the additional benefit of limiting the ability of a strain to become resistant to treatment. In a recent paper published in Frontiers in Pharmacology, Alfaro et al. describe a promising safety profile of an aerosolized oligonucleotide and peptide treatment against pneumonia by targeting Toll-like Receptors (TLR).

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Blog Post

Reflections on Advances in Medicinal Oligonucleotides

  • Oligos Are Not “Magic Bullets”
  • Oligos Have, Nevertheless, Enabled New Drug Paradigms
  • Oligos Continue to Attract Significant Corporate Investments

Oligos didn’t quite prove to be the new paradigm for a speedy concept-to-clinic solution.

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Blog Post

Hot Topic in Oligonucleotide Therapeutics: Nanomedicine
  • What is it?
  • Why is it Hot?
  • How do Nucleic Acids Fit in?

Nanomedicine, like almost everything these days, has a wiki site; however, it simply defines nanomedicine as “the medical application of nanotechnology,” which begs questions of what’s nanotechnology and what are some of these applications?

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