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Research Update

Unraveling Cell Specific Muscular Disorders with TriLink's Cas9

Recently, researchers from University of Texas used TriLink’s Cas9 mRNA to uncover a possible cause of one form of congenital myopathy.

Congenital myopathy is a group of inherited muscle disorders that occurs in approximately 1 in 10,000 people. Symptoms are often identified at birth and causes muscle weakness, a delay in development, and in some cases may lead to death due to respiratory distress.

"To date, there are no effective therapies for any of these disorders, and much remains to be learned about the underlying disease mechanisms," the researchers note.

The article, published last month in Journal of Clinical Investigation, used TriLink’s Cas9 mRNA to knock out Kelch family protein Klhl31, in mice. The Kelch super family of proteins primarily affect protein stability, acting as substrate specific adapters that modulate ubiquination.

In previous studies, mice deficient of other select Kelch family proteins have shown characteristics of nemaline myopathy, which is...

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Gene Editing Components

Of the many gene editing tools available none can deliver TriLink’s quality. In addition to catalog Cas9 and NLS-Cre Recombinase mRNA, custom synthesis of Zinc-finger Nuclease and TALEN mRNA is available. All our gene editing mRNA is available with CleanCap™, TriLink’s new capping technology that provides improved expression enabling superior performance for all your gene editing projects.

Don’t see what you need, order a custom synthesis. Available at scales ranging from micrograms to grams, TriLink's custom synthesis services include a wide variety of modifications and purification options to meet your specific application or program needs.

All TriLink mRNA are also available in GMP Grade for early Phase Clinical Trials.

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What information is required for a custom mRNA quote?

Step 1: Identify the Source of Transcription Template: There are two primary options for the template source. We can synthesize and clone your sequence into our specially designed plasmid or you may submit your own template(PCR product or plasmid). The template must contain the elements as described in the "Transcription...

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