|October 2018 Research Update
CleanTag® Supports New Method to Detect Reactivation of a Common Virus
Using TriLink CleanTag technology, researchers at the University of Wurzburg have developed a deep sequencing method that more reliably detects reactivation of HHV-6, a virus that infects nearly 100% of humans by early childhood.
Once infected, the virus incorporates into the subtelomeric end of chromosomes of the host, typically establishing life-long latency without complications.
However, under certain circumstances, the virus can be triggered to reactivate later in life. Although it's still unclear exactly how the virus is reactivated, it can reactivate in the lungs, heart, brain, kidney, and gastrointestinal tract, particularly in people with immune deficiencies (or people with conditions requiring immune suppression, such as transplant patients). HHV-6 reactivation can cause a variety of clinical manifestations, including encephalitis, bone marrow suppression, pneumonitis, and in extreme cases, even death.
One substantial problem in treating these cases is how difficult it is to identify HHV-6 reactivation (which includes types HHV-6A and B).
"Germ line inheritance of chromosomally integrated HHV-6 makes viral DNA-based analysis difficult for determination of early stages of viral activation,"...