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October 2018 Research Update

CleanTag® Supports New Method to Detect Reactivation of a Common Virus

Using TriLink CleanTag technology, researchers at the University of Wurzburg have developed a deep sequencing method that more reliably detects reactivation of HHV-6, a virus that infects nearly 100% of humans by early childhood.

Once infected, the virus incorporates into the subtelomeric end of chromosomes of the host, typically establishing life-long latency without complications.

However, under certain circumstances, the virus can be triggered to reactivate later in life. Although it's still unclear exactly how the virus is reactivated, it can reactivate in the lungs, heart, brain, kidney, and gastrointestinal tract, particularly in people with immune deficiencies (or people with conditions requiring immune suppression, such as transplant patients). HHV-6 reactivation can cause a variety of clinical manifestations, including encephalitis, bone marrow suppression, pneumonitis, and in extreme cases, even death.

One substantial problem in treating these cases is how difficult it is to identify HHV-6 reactivation (which includes types HHV-6A and B).

"Germ line inheritance of chromosomally integrated HHV-6 makes viral DNA-based analysis difficult for determination of early stages of viral activation,"...

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Association for Molecular Pathology (AMP)
Booth # 1503
Nov 1- 3, 2018
San Antonio, TX

EuroTIDES
Booth # 34
Nov 6-11, 2018
Amsterdam, NL

mRNA Health Conference
Nov 12-13, 2018
Boston, MA
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Modified Oligonucleotides: Core to Molecular Diagnostics, Therapeutics, Genomics, and Gene Editing

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Wednesday, October 31, 2018 in San Antonio, TX

At the Association of Molecular Pathology (AMP) Annual Meeting where we will present an overview of current oligonucleotide synthesis methods that allow the production of highly modified oligonucleotides.

Duration: 3:00 pm - 3:50 pm

Location: Henry B. Gonzalez Convention Center

Room: 304AB

Hosted By: TriLink BioTechnologies

Presented by: Dr. Lyle Arnold


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Do you offer a kit for small RNA library prep that is compatible with the Ion Torrent sequencing platform?

CleanTag Small RNA Library Prep Kit (Cat# L-3206) contains adapters compatible with the Illumina® sequencing platform. However you can easily convert your tagged library into Ion Torrent™ compatible sequences during the PCR step. Contact us to discuss.

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Zone In With The Zon Blog Post

Highlights from the 14th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS 2018)

The idea for the OTS was conceived in 2001 by an international group of renowned oligonucleotide scientists, who hoped to bring together expertise from different angles of oligonucleotide research and create synergies to help the field accomplish its full therapeutic potential...

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