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December 2018 Research Update

mRNA: Restoring PTEN and Reducing Tumors without Toxicity

Researchers at Harvard University have successfully developed a new mRNA-based therapeutic approach that targets the PTEN (phosphatase and tensin homologue deleted on chromosome 10) pathway, which contributes to nearly 50% of cases of metastatic castration-resistant prostate cancer. PTEN is a tumor suppressor gene that opposes the action of PI3K, a critical enzyme for anti-apoptotic, pro-tumorigenic Akt activation.

The complexity of cancer requires a multifunctional therapeutic approach. A combination of surgery, chemotherapy, and radiation has been a mainstay for decades, but new approaches are developing rapidly, allowing for more innovative and comprehensive solutions.

Among these new types of therapies, mRNA-based therapies have proven to be especially promising. A growing understanding of the immunogenicity of mRNA has opened the field to both vaccine development (by enhancing its immunogenicity) and protein correction (by diminishing its immunogenicity).

Overall, gene editing (primarily through introduction of DNA) and protein correction (primarily through introduction of mRNA or siRNA)...

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*10% discount valid on purchase of select full-price products from October 25, 2018 to December 21, 2018, 11:59pm PST with code Thanks10. This promotion is open to customers that do not qualify as distributors of TriLink BioTechnologies. Discount applies to orders that exceed $2000.00 USD before discount offer is applied, with a maximum eligible discount of $5000.00 USD. Offer valid for catalog sizing and excludes bulk quotes or large-scale orders. Discount applies to list price in effect at the time order is received by TriLink BioTechnologies. Offer cannot be applied to previous purchases and cannot be combined with other discounts or promotions. Offer void where prohibited, licensed or restricted by federal, state, provincial, or local laws or regulation or agency/institutional policy. Other restrictions may apply. Terms are subject to change.

 
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I've identified the target sequence for a CRISPR Cas9 gene editing experiment. What components do I need?

To attain unmatched consistency between your CRISPR experimental replicates use TriLink CleanCap® Cas9 mRNA and high quality sgRNA. sgRNA, also known as single guide RNA, is a chimeric RNA composed of crRNA and tracrRNA, connected by a short RNA linker.

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Zone In With The Zon Blog Post

Tagging Modified mRNA with TAG (Transglycosylation at Guanosine)

Back in 2013, I wrote a blog titled Modified mRNA Mania, which drew attention to the then nascent development of an entirely new field of therapeutics, based on the use of biosynthetic modified mRNA (mod-RNA). I also wrote a more recent blog about this still trending field, titled Deluge of mRNA...

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