Ganciclovir Triphosphate

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N-9001
9-(1,3-Dihydroxy-2-propoxymethyl)guanine-5'-Triphosphate, GCV-TP
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SKU Unit Size Price Qty
N-9001-1 1 µmole
$180.00
N-9001-5 5 µmole
$830.00
N-9001-10 10 µmole
$1,477.00
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Description

Ganciclovir is a synthetic acyclic-DNA guanine derivative, where the C2’ carbon bond is absent. Ganciclovir Triphosphate (ganciclovir-TP, GCV-TP), the active metabolite of ganciclovir, is thought to disrupt viral DNA synthesis by competitive inhibition of viral DNA polymerases and by incorporation into viral DNA, to result in eventual termination of viral DNA elongation. Ganciclovir was first published as 2'-Nor-2'-deoxyguanosine (2'NDG), with noted effectiveness in treating acute herpes simplex infections in mice. Recently it has been studied as an Epstein-Barr Virus treatment, as well as a prostate cancer, human cytomegalovirus (HCMV) retinitis and CMV antigeemia preemptive treatment. The triphosphorylated form (GCV-TP) is an important control in this research.

Product Details

Catalog No N-9001
Purity ≥95% by AX-HPLC
Extinction Coefficient 13,600 Lmol-1cm-1 at 252 nm
Molecular Formula C9H16N5O13P3 (free acid)
Molecular Weight 495.20 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 9-(1,3-Dihydroxy-2-propoxymethyl)guanine-5'-Triphosphate, GCV-TP
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Guanosine
Sugar Type(s) RNA
Nucleotide Category Non-nucleotide

Technical Documents




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