N1-Ethylpseudouridine-5'-Triphosphate - (N-1102)
N1-Ethylpseudo-UTP, 1-Ethylpseudo-UTP
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N-1102
Description
A modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-ethylpseudouridine can reduce the immunogenicity of the resulting mRNA.
Product details
| Catalog No | N-1102 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 7,800 Lmol-1cm-1 at 271 nm |
| Molecular Formula | C11H19N2O15P3 (free acid) |
| Molecular Weight | 512.20 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | N1-Ethylpseudo-UTP, 1-Ethylpseudo-UTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Pseudouridine |
| Sugar Type(s) | RNA |
| Nucleotide Category | Base Modified RNA |
Technical documents
N-1102 Safety Data Sheet
Products faqs
Ask an Expert
Certificate of analysis
CoA search tool
Intellectual property
Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.
TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.
References
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- Stadler, Christiane R.; Bähr-Mahmud, Hayat; Celik, Leyla; Hebich, Bernhard; Roth, Alexandra S.; Roth, René P.; Karikó, Katalin; Türeci, Özlem; Sahin, Ugur . Elimination of large tumors in mice by mRNA-encoded bispecific antibodies.
- Wagner, Tyler E.; Becraft, Jacob R.; Bodner, Katie; Teague, Brian; Zhang, Xin; Woo, Amanda; Porter, Ely; Alburquerque, Bremy; Dobosh, Brian; Andries, Oliwia; Sanders, Niek N.; Beal, Jacob; Densmore, Douglas; Kitada, Tasuku; Weiss, Ron . Small-molecule-based regulation of RNA-delivered circuits in mammalian cells.
