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3'-Deoxythymidine-5'-O-(1-Thiotriphosphate) - (N-8012)

Alpha Thiol ddTTP, 1-Thio-ddTTP
In stock
Product SKU Unit Size Price Qty
N-8012-1 1 µmole
N-8012-5 5 µmole
N-8012-10 10 µmole
2',3'-Dideoxythymidine-5'-O-(1-Thiotriphosphate) is a sugar modified nucleoside triphosphate where the 2' and 3' hydroxyl groups are absent, resulting in chain termination. This ddTTP analog also contains a 1-Thiotriphosphate which results in a nuclease resistant phosphorothioate linkage. The inability of polymerases to extend from a dideoxy nucleotide causes chain termination and is useful in antiviral research and in a variety of biotechnology applications.
Product details
Catalog No N-8012
Purity ≥90% by AX-HPLC
Extinction Coefficient 9,650 Lmol-1cm-1 at 267 nm
Molecular Formula C10H17N2O12P3S (free acid)
Molecular Weight 482.20 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) Alpha Thiol ddTTP, 1-Thio-ddTTP
Backbone 5'-O-(1-Thiotriphosphate)
Base Analog(s) Thymidine
Sugar Type(s) 3'-Deoxy
Nucleotide Category Phosphate Modified
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