5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate - (N-2060)
5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
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N-2060
Description
Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.
Product details
| Catalog No | N-2060 |
|---|---|
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 7,700 Lmol-1cm-1 at 275 nm |
| Molecular Formula | C10H18N3O14P3 (free acid) |
| Molecular Weight | 497.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H2O |
| Recommended Storage | -20°C or below |
| Other Name(s) | 5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Cytidine |
| Sugar Type(s) | DNA |
| Nucleotide Category | Base Modified DNA |
Technical documents
N-2060 Safety Data Sheet
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Certificate of analysis
CoA search tool
Intellectual property
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References
- Wu, Susan C.; Zhang, Yi . Active DNA demethylation: many roads lead to Rome.
- Münzel, Martin; Globisch, Daniel; Carell, Thomas . 5-Hydroxymethylcytosine, the sixth base of the genome.
- McKernan, Kevin J.; Spangler, Jessica; Zhang, Lei; Tadigotla, Vasisht; McLaughlin, Stephen; Warner, Jason; Zare, Amir; Boles, Richard G. . Expanded genetic codes in next generation sequencing enable decontamination and mitochondrial enrichment.
- Li, Zheng; Gu, Tian-Peng; Weber, Alain R.; Shen, Jia-Zhen; Li, Bin-Zhong; Xie, Zhi-Guo; Yin, Ruichuan; Guo, Fan; Liu, Xiaomeng; Tang, Fuchou; Wang, Hailin; Schär, Primo; Xu, Guo-Liang . Gadd45a promotes DNA demethylation through TDG.
- Jiang, Wenjing; Wu, Linni; Duan, Junling; Yin, Huanshun; Ai, Shiyun . Ultrasensitive electrochemiluminescence immunosensor for 5-hydroxymethylcytosine detection based on Fe(3)O(4)@SiO(2) nanoparticles and PAMAM dendrimers.
- Li, F;Wang, S;Yin, H;Chen, Y;Zhou, Y;Huang, J;Ai, S; . Photoelectrochemical Biosensor for DNA Formylation Detection in Genomic DNA of Maize Seedlings Based on Black Tio2-Enhanced Photoactivity of MoS2/WS2 Heterojunction
- Zhou, Y;Yin, H;Sui, C;Wang, Y;Ai, S; . Photoelectrochemical detection of 5-hydroxymethylcytosine in genomic DNA based on M. HhaI methyltransferase catalytic covalent bonding
- Wang, Q;Yin, H;Ding, J;Zhou, Y;Ai, S; . WS2/Bi/BiOBr Nanostructures for Photoelectrochemical Sensing of 5-Formyluracil-2?-deoxyuridine-5?-triphosphate through Hemin/G-Quadruplex Double Signal Amplification
- Wang, Q;Yin, H;Zhou, Y;Cao, L;Yu, Z;Xu, Y;Ai, S; . Photoelectrochemical biosensor for 5?formylcytosine based on WS 2 /Bi/ Bi 2 O 2 CO 3 nanocomposite and rolling circle amplification
- Ding, J;Gao, L;Cao, L;Zhou, Y;Wang, H;Duan, J;Yin, H;Sun, J;Ai, S; . Photoelectrochemical immunosensor for DNA hydroxymethylation based on PTCA-sensitized perovskite Bi4TaO8Cl
