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5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate - (N-2060)

5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
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Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.
Product details
Catalog No N-2060
Purity ≥90% by AX-HPLC
Extinction Coefficient 7,700 Lmol-1cm-1 at 275 nm
Molecular Formula C10H18N3O14P3 (free acid)
Molecular Weight 497.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Cytidine
Sugar Type(s) DNA
Nucleotide Category Base Modified DNA
Technical documents

N-2060 Safety Data Sheet

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Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.

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  1. Wu, Susan C.; Zhang, Yi . Active DNA demethylation: many roads lead to Rome.
  2. Münzel, Martin; Globisch, Daniel; Carell, Thomas . 5-Hydroxymethylcytosine, the sixth base of the genome.
  3. McKernan, Kevin J.; Spangler, Jessica; Zhang, Lei; Tadigotla, Vasisht; McLaughlin, Stephen; Warner, Jason; Zare, Amir; Boles, Richard G. . Expanded genetic codes in next generation sequencing enable decontamination and mitochondrial enrichment.
  4. Li, Zheng; Gu, Tian-Peng; Weber, Alain R.; Shen, Jia-Zhen; Li, Bin-Zhong; Xie, Zhi-Guo; Yin, Ruichuan; Guo, Fan; Liu, Xiaomeng; Tang, Fuchou; Wang, Hailin; Schär, Primo; Xu, Guo-Liang . Gadd45a promotes DNA demethylation through TDG.
  5. Jiang, Wenjing; Wu, Linni; Duan, Junling; Yin, Huanshun; Ai, Shiyun . Ultrasensitive electrochemiluminescence immunosensor for 5-hydroxymethylcytosine detection based on Fe(3)O(4)@SiO(2) nanoparticles and PAMAM dendrimers.
  6. Li, F;Wang, S;Yin, H;Chen, Y;Zhou, Y;Huang, J;Ai, S; . Photoelectrochemical Biosensor for DNA Formylation Detection in Genomic DNA of Maize Seedlings Based on Black Tio2-Enhanced Photoactivity of MoS2/WS2 Heterojunction
  7. Zhou, Y;Yin, H;Sui, C;Wang, Y;Ai, S; . Photoelectrochemical detection of 5-hydroxymethylcytosine in genomic DNA based on M. HhaI methyltransferase catalytic covalent bonding
  8. Wang, Q;Yin, H;Ding, J;Zhou, Y;Ai, S; . WS2/Bi/BiOBr Nanostructures for Photoelectrochemical Sensing of 5-Formyluracil-2?-deoxyuridine-5?-triphosphate through Hemin/G-Quadruplex Double Signal Amplification
  9. Wang, Q;Yin, H;Zhou, Y;Cao, L;Yu, Z;Xu, Y;Ai, S; . Photoelectrochemical biosensor for 5?formylcytosine based on WS 2 /Bi/ Bi 2 O 2 CO 3 nanocomposite and rolling circle amplification
  10. Ding, J;Gao, L;Cao, L;Zhou, Y;Wang, H;Duan, J;Yin, H;Sun, J;Ai, S; . Photoelectrochemical immunosensor for DNA hydroxymethylation based on PTCA-sensitized perovskite Bi4TaO8Cl
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