5-Hydroxymethyl-2’-deoxycytidine-5’-Triphosphate

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N-2060
5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
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SKU Unit Size Price Qty
N-2060-1 1 µmole
$91.00
N-2060-5 5 µmole
$438.00
N-2060-10 10 µmole
$750.00
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Description

Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.

Product Details

Catalog No N-2060
Purity ≥90% by AX-HPLC
Extinction Coefficient 7,700 Lmol-1cm-1 at 275 nm
Molecular Formula C10H18N3O14P3 (free acid)
Molecular Weight 497.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Cytidine
Sugar Type(s) DNA
Nucleotide Category Base Modified DNA

Technical Documents




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