Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.
Product Details
Catalog No
N-2060
Purity
≥90% by AX-HPLC
Extinction Coefficient
7,700 Lmol-1cm-1 at 275 nm
Molecular Formula
C10H18N3O14P3 (free acid)
Molecular Weight
497.10 g/mole (free acid)
Salt Form
Li+
Concentration
100 mM
Buffer
H2O
Recommended Storage
-20°C or below
Other Name(s)
5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
Application
Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
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