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LUMI-lab: A foundation model-driven autonomous platform enabling discovery of new ionizable lipid designs for mRNA delivery
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LUMI-lab: A foundation model-driven autonomous platform enabling discovery of new ionizable lipid designs for mRNA delivery

biochemistry modified mRNA nanoparticles proteins delivery nucleid acids bacteria modified RNA
Posted in: Nucleic Acids
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CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
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CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

biochemistry modified mRNA nanoparticles proteins delivery nucleid acids bacteria PCR methylation modified RNA
Posted in: Nucleic Acids
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Protein folding drives rapid evolutionary change in trait correlations of single proteins
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Protein folding drives rapid evolutionary change in trait correlations of single proteins

biochemistry nucleid acids bacteria PCR protein unnatural base pairs
Posted in: Nucleic Acids
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TL Cloaking mRNA to Control Stability and Translation in Cells
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TL Cloaking mRNA to Control Stability and Translation in Cells

TL Nanoparticles TL nucleic acids TL modified mRNA TL modified RNA
Posted in: Nucleic Acids Therapeutics
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TL Perspectives on In Vitro Transcription (IVT) mRNA Sequence Optimization
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TL Perspectives on In Vitro Transcription (IVT) mRNA Sequence Optimization

This blog provides some perspective on published strategies for this type of sequence optimization, which is alternatively referred to sequence engineering. This topic has been trending upwards in recent years, as indicated by the linear forecast dashed line shown in this chart reports found by word searching the NIH PubMed database for 2013 – 2020.

Posted in: Nucleic Acids
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TL Aerosol Delivery of Naked mRNA – Part 2 

TL Nanoparticles TL delivery TL mRNA TL nucleic acids TL proteins TL pseudouridine TL modified mRNA
Posted in: Nucleic Acids Therapeutics
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TL Sulfur-Modified Phosphorothioate Linkages in Bacterial DNA

TL DNA Structure TL bacteria TL microbes TL DNA TL nucleic acids TL proteins TL Biochemistry TL microbiome
Posted in: Nucleic Acids
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TL Specificity Enhancement of PCR and Other DNA Polymerization Using Phosphorothioate-Modified dNTPs

TL PCR TL nucleic acids
Posted in: Nucleic Acids Diagnostics
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TL Feasibility of Antisense Oligonucleotides as DNA Insecticides

TL gene engineering TL PCR TL oligo synthesis TL RNA TL nucleic acids TL Biochemistry TL antisense
Posted in: Nucleic Acids RNA Interference (RNAi) Antisense
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TL New Chemical Ligations Compatible with Polymerase-Mediated Nucleic Acid Assembly 

TL Sanger Sequencing TL sequencing TL mRNA TL PCR TL oligo synthesis TL RNA TL nucleic acids
Posted in: Nucleic Acids Modified Oligos NGS
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    Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
    Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo
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    LUMI-lab: A foundation model-driven autonomous platform enabling discovery of new ionizable lipid designs for mRNA delivery
    LUMI-lab: A foundation model-driven autonomous platform enabling discovery of new ionizable lipid designs for mRNA delivery
    Loading...
    273 view(s)
    CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
    CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
    Loading...
    209 view(s)
    Protein folding drives rapid evolutionary change in trait correlations of single proteins
    Protein folding drives rapid evolutionary change in trait correlations of single proteins
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    237 view(s)
    High-throughput algorithmic optimization of in vitro transcription
    High-throughput algorithmic optimization of in vitro transcription
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    722 view(s)