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Modified nucleotide triphosphates

A proven solution for mRNA therapeutic development

The use of modified nucleoside triphosphates (NTPs) has been instrumental in advancing mRNA therapeutic innovation, and TriLink® has been partnering with mRNA pioneers since day one. Our modified NTPs are used in vaccine and therapeutic programs worldwide and continue to fuel the development of novel therapeutics. From research use to the first-ever GMP-grade offering, TriLink provides a comprehensive portfolio of off-the-shelf, scalable, chemically synthesized NTP to help accelerate your mRNA therapeutic or vaccine development.

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Promote robust expression and minimize immunogenicity

Incorporating modified uridines into mRNA products help reduce immunogenicity, enhance mRNA stability, and increase translational capacity for more successful therapeutic action. To help you optimize mRNA performance, TriLink offers >150 modified NTPs in catalog and customizable formats—from RUO to GMP-grade—for your diverse applications.

Widely used modified NTPs in mRNA therapeutic development

N1-Methyl-Pseudouridine-5'-Triphosphate

5-Methoxyuridine-5'-Triphosphate

Pseudouridine-5'-Triphosphate

5-Methylcytidine-5'-Triphosphate

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Access, formats and modifications

As an NTP manufacturer with 20+ years of experience, TriLink partners with biotechs, startups, and academia to help achieve your research and therapeutic goals.

Built, quality, and scale

TriLink provides extensive knowledge of nucleotide synthesis and purification as well as an established quality system in place to help accelerate your projects..

Expertise and offerings

Specializing in mRNA capping technology and NTP manufacturing, TriLink offers standard and modified NTPs in RUO and GMP grades.

NTP Brochure Download

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Modified nucleotide triphosphates

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