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2',3'-Dideoxyguanosine-5'-Triphosphate - (N-4002)


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2',3'-Dideoxyguanosine-5'-Triphosphate (ddGTP) is a sugar modified nucleoside triphosphate, where the 2' and 3' hydroxyl groups are absent, resulting in chain termination. The inability of polymerases to extend from a dideoxy nucleotide causes the chain termination and is useful in a variety of biotechnology applications. ddGTP is used in cycle sequencing, enzyme mechanistic studies and for producing RNA and DNA sequences that cannot be extended by polymerases or joined by DNA ligases. Another notable application that utilizes a primer terminated on the 3′ end with a dideoxy modification is pyrophosphorolysis-activated polymerization (PAP). This technique is valuable for the detection of rare mutations. "I use ddNTPs from TriLink for sequencing using DNA and RNA as templates and it always gives me good results." Michal Legiewicz Research Scientist Yale University
Product details
Catalog No N-4002
Purity ≥95% by AX-HPLC
Extinction Coefficient 13,600 Lmol-1cm-1 at 252 nm
Molecular Formula C10H16N5O12P3 (free acid)
Molecular Weight 491.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) ddGTP
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Guanosine
Nucleotide Category Sugar Modified
Technical documents

N-4002 Safety Data Sheet

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Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.

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