2',3'-Dideoxyinosine-5'-Triphosphate

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N-4017
ddITP, Didanosine triphosphate
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SKU Unit Size Price Qty
N-4017-1 1 µmole
$180.00
N-4017-5 5 µmole
$806.00
N-4017-10 10 µmole
$1,434.00
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Description

2',3'-Dideoxyinosine-5'-Triphosphate (ddITP) is a sugar modified nucleoside triphosphate, where the 2' and 3' hydroxyl groups are absent, resulting in chain termination. The inability of polymerases to extend from a dideoxy nucleotide causes the chain termination and is useful in a variety of biotechnology applications. ddITP is used in cycle sequencing, enzyme mechanistic studies and for producing RNA and DNA sequences that cannot be extended by polymerases or joined by DNA ligases. Another notable application that utilizes a primer terminated on the 3′ end with a dideoxy modification is pyrophosphorolysis-activated polymerization (PAP). This technique is valuable for the detection of rare mutations.

Product Details

Catalog No N-4017
Purity ≥90% by AX-HPLC
Extinction Coefficient 12,300 Lmol-1cm-1 at 248 nm
Molecular Formula C10H15N4O12P3 (free acid)
Molecular Weight 476.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) ddITP, Didanosine triphosphate
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Guanosine, Inosine
Nucleotide Category Sugar Modified

Technical Documents




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